Target name

P41146: Nociceptin receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

  Database links

Uniprot primary ID P41146
GRCP SARfari Variant Name hOPRL1_174
PDB ID 4EA3
DrugBank ID
BioGrid ID 111032
GuidetoPHARMACOLOGY ID 320
PharmGKB ID PA31944
KEGG ID hsa:4987
Entrez Gene (Gene ID) 4987
BindingDB P41146

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.75 0.81 0.82 0.88 0.62 Download
FP4 fingerprints 0.880 0.740 0.810 0.820 0.870 0.620 Download
MACCS fingerprints 0.770 0.680 0.720 0.740 0.790 0.450 Download
Daylight fingerprints 0.750 0.820 0.790 0.780 0.850 0.570 Download
ECFP2 fingerprints 0.900 0.870 0.880 0.890 0.950 0.770 Download
ECFP4 fingerprints 0.930 0.930 0.930 0.930 0.970 0.860 Download
ECFP6 fingerprints 0.920 0.940 0.930 0.930 0.970 0.860 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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