Target name

P41149: Melanocortin receptor 5


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

  Database links

Uniprot primary ID P41149
GRCP SARfari Variant Name mMC5R_1492
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 286
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID)
BindingDB P41149

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.98 0.74 0.86 0.88 0.89 0.75 Download
FP4 fingerprints 0.980 0.730 0.850 0.870 0.900 0.730 Download
MACCS fingerprints 0.970 0.740 0.860 0.870 0.900 0.730 Download
Daylight fingerprints 0.950 0.760 0.860 0.870 0.870 0.730 Download
ECFP2 fingerprints 0.960 0.730 0.850 0.860 0.900 0.720 Download
ECFP4 fingerprints 0.940 0.740 0.840 0.860 0.910 0.700 Download
ECFP6 fingerprints 0.930 0.770 0.850 0.860 0.910 0.710 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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