Target name

P41231: P2Y purinoceptor 2


  Protein function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

  Database links

Uniprot primary ID P41231
GRCP SARfari Variant Name hP2RY2_175
PDB ID 1Z8E
DrugBank ID DB04786
BioGrid ID 111068
GuidetoPHARMACOLOGY ID 324
PharmGKB ID PA32870
KEGG ID hsa:5029
Entrez Gene (Gene ID) 5029
BindingDB P41231

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.89 0.8 0.85 0.85 0.86 0.7 Download
FP4 fingerprints 0.920 0.790 0.860 0.870 0.830 0.720 Download
MACCS fingerprints 0.920 0.800 0.860 0.870 0.860 0.730 Download
Daylight fingerprints 0.870 0.800 0.830 0.840 0.870 0.660 Download
ECFP2 fingerprints 0.920 0.800 0.860 0.870 0.830 0.730 Download
ECFP4 fingerprints 0.920 0.800 0.860 0.870 0.860 0.730 Download
ECFP6 fingerprints 0.920 0.810 0.870 0.870 0.870 0.740 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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