Target name

P41595: 5-hydroxytryptamine receptor 2B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca

  Database links

Uniprot primary ID P41595
GRCP SARfari Variant Name h5HT2B_176
PDB ID 4NC3 4IB4
DrugBank ID DB06148 DB01142 DB01049 DB00320 DB01239 DB00508 DB00370 DB00543 DB00589 DB06216 DB00216 DB00334 DB01392 DB00805 DB00413 DB01200 DB01186 DB00477 DB01221 DB00714 DB00247 DB00268 DB00248 DB01242
BioGrid ID 109589
GuidetoPHARMACOLOGY ID 7
PharmGKB ID PA29554
KEGG ID hsa:3357
Entrez Gene (Gene ID) 3357
BindingDB P41595

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.71 0.72 0.73 0.8 0.45 Download
FP4 fingerprints 0.800 0.670 0.730 0.750 0.770 0.470 Download
MACCS fingerprints 0.760 0.610 0.680 0.710 0.730 0.370 Download
Daylight fingerprints 0.620 0.700 0.660 0.650 0.720 0.330 Download
ECFP2 fingerprints 0.820 0.720 0.770 0.780 0.860 0.540 Download
ECFP4 fingerprints 0.810 0.800 0.810 0.810 0.900 0.610 Download
ECFP6 fingerprints 0.770 0.830 0.800 0.800 0.890 0.610 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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