Target name

P41597: C-C chemokine receptor type 2


  Protein function

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.

  Database links

Uniprot primary ID P41597
GRCP SARfari Variant Name hCCR2_177
PDB ID 1KAD 1KP1
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 59
PharmGKB ID PA26167
KEGG ID hsa:729230
Entrez Gene (Gene ID) 729230
BindingDB P41597

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.8 0.81 0.81 0.8 0.9 0.61 Download
FP4 fingerprints 0.780 0.850 0.820 0.810 0.870 0.630 Download
MACCS fingerprints 0.780 0.820 0.800 0.790 0.860 0.590 Download
Daylight fingerprints 0.790 0.820 0.810 0.800 0.860 0.610 Download
ECFP2 fingerprints 0.820 0.920 0.870 0.860 0.950 0.740 Download
ECFP4 fingerprints 0.860 0.940 0.900 0.900 0.970 0.800 Download
ECFP6 fingerprints 0.840 0.950 0.890 0.890 0.970 0.790 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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