Target name

P41968: Melanocortin receptor 3


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.

  Database links

Uniprot primary ID P41968
GRCP SARfari Variant Name hMC3R_178
PDB ID
DrugBank ID
BioGrid ID 110329
GuidetoPHARMACOLOGY ID 284
PharmGKB ID PA30675
KEGG ID hsa:4159
Entrez Gene (Gene ID) 4159
BindingDB P41968

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.89 0.77 0.83 0.84 0.87 0.67 Download
FP4 fingerprints 0.890 0.770 0.830 0.840 0.860 0.660 Download
MACCS fingerprints 0.870 0.790 0.830 0.840 0.870 0.660 Download
Daylight fingerprints 0.830 0.820 0.820 0.830 0.860 0.650 Download
ECFP2 fingerprints 0.890 0.800 0.840 0.850 0.880 0.690 Download
ECFP4 fingerprints 0.880 0.820 0.850 0.860 0.900 0.710 Download
ECFP6 fingerprints 0.850 0.850 0.850 0.850 0.900 0.700 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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