Target name

P43088: Prostaglandin F2-alpha receptor


  Protein function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform

  Database links

Uniprot primary ID P43088
GRCP SARfari Variant Name hPTGFR_179
PDB ID
DrugBank ID DB00654 DB00905 DB00287 DB08819 DB01160
BioGrid ID 111709
GuidetoPHARMACOLOGY ID 344
PharmGKB ID PA290
KEGG ID hsa:5737
Entrez Gene (Gene ID) 5737
BindingDB P43088

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.83 0.81 0.81 0.87 0.62 Download
FP4 fingerprints 0.810 0.660 0.740 0.750 0.780 0.480 Download
MACCS fingerprints 0.780 0.780 0.780 0.780 0.840 0.560 Download
Daylight fingerprints 0.640 0.690 0.660 0.660 0.700 0.330 Download
ECFP2 fingerprints 0.810 0.740 0.770 0.780 0.840 0.550 Download
ECFP4 fingerprints 0.830 0.820 0.830 0.830 0.900 0.660 Download
ECFP6 fingerprints 0.860 0.860 0.860 0.860 0.920 0.710 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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