Target name

P43115: Prostaglandin E2 receptor EP3 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

  Database links

Uniprot primary ID P43115
GRCP SARfari Variant Name hPTGER3_180
PDB ID
DrugBank ID DB00917 DB00905 DB00929
BioGrid ID 111705
GuidetoPHARMACOLOGY ID 342
PharmGKB ID PA288
KEGG ID hsa:5733
Entrez Gene (Gene ID) 5733
BindingDB P43115

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.72 0.96 0.84 0.82 0.94 0.7 Download
FP4 fingerprints 0.840 0.890 0.860 0.860 0.940 0.730 Download
MACCS fingerprints 0.690 0.900 0.790 0.770 0.890 0.600 Download
Daylight fingerprints 0.690 0.800 0.740 0.730 0.790 0.490 Download
ECFP2 fingerprints 0.880 0.920 0.900 0.900 0.950 0.800 Download
ECFP4 fingerprints 0.880 0.950 0.910 0.910 0.960 0.830 Download
ECFP6 fingerprints 0.840 0.960 0.900 0.890 0.960 0.800 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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