Target name

P43116: Prostaglandin E2 receptor EP2 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

  Database links

Uniprot primary ID P43116
GRCP SARfari Variant Name hPTGER2_181
PDB ID
DrugBank ID DB00917 DB00770 DB00929
BioGrid ID
GuidetoPHARMACOLOGY ID 341
PharmGKB ID PA287
KEGG ID hsa:5732
Entrez Gene (Gene ID) 5732
BindingDB P43116

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.75 0.74 0.74 0.75 0.82 0.49 Download
FP4 fingerprints 0.830 0.660 0.750 0.770 0.810 0.500 Download
MACCS fingerprints 0.660 0.710 0.680 0.680 0.780 0.370 Download
Daylight fingerprints 0.720 0.660 0.690 0.700 0.710 0.380 Download
ECFP2 fingerprints 0.800 0.660 0.730 0.750 0.810 0.470 Download
ECFP4 fingerprints 0.840 0.800 0.820 0.830 0.880 0.650 Download
ECFP6 fingerprints 0.820 0.850 0.830 0.830 0.880 0.670 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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