Target name

P43140: Alpha-1A adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).

  Database links

Uniprot primary ID P43140
GRCP SARfari Variant Name rA1AA_1499
PDB ID 2F75
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 22
PharmGKB ID
KEGG ID rno:29412
Entrez Gene (Gene ID) 29412
BindingDB P43140

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.71 0.75 0.76 0.84 0.5 Download
FP4 fingerprints 0.780 0.660 0.720 0.740 0.800 0.450 Download
MACCS fingerprints 0.770 0.640 0.710 0.720 0.770 0.420 Download
Daylight fingerprints 0.710 0.650 0.680 0.690 0.730 0.350 Download
ECFP2 fingerprints 0.860 0.740 0.800 0.810 0.880 0.600 Download
ECFP4 fingerprints 0.870 0.810 0.840 0.840 0.910 0.680 Download
ECFP6 fingerprints 0.840 0.830 0.840 0.840 0.910 0.680 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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