Target name

P47898: 5-hydroxytryptamine receptor 5A


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

  Database links

Uniprot primary ID P47898
GRCP SARfari Variant Name h5HT5A_194
PDB ID
DrugBank ID DB00408 DB00334 DB06216
BioGrid ID
GuidetoPHARMACOLOGY ID 10
PharmGKB ID PA29558
KEGG ID hsa:3361
Entrez Gene (Gene ID) 3361
BindingDB P47898

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.67 0.95 0.81 0.78 0.88 0.64 Download
FP4 fingerprints 0.740 0.740 0.740 0.740 0.810 0.480 Download
MACCS fingerprints 0.590 0.790 0.690 0.660 0.800 0.390 Download
Daylight fingerprints 0.700 0.760 0.730 0.720 0.760 0.470 Download
ECFP2 fingerprints 0.770 0.640 0.700 0.720 0.820 0.410 Download
ECFP4 fingerprints 0.830 0.790 0.810 0.810 0.890 0.620 Download
ECFP6 fingerprints 0.810 0.820 0.820 0.820 0.900 0.630 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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