Target name

P47900: P2Y purinoceptor 1


  Protein function

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

  Database links

Uniprot primary ID P47900
GRCP SARfari Variant Name hP2RY1_195
PDB ID 4XNV 1Y36 4XNW
DrugBank ID
BioGrid ID 111067
GuidetoPHARMACOLOGY ID 323
PharmGKB ID PA32868
KEGG ID hsa:5028
Entrez Gene (Gene ID) 5028
BindingDB P47900

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.68 0.81 0.74 0.73 0.82 0.49 Download
FP4 fingerprints 0.810 0.730 0.770 0.780 0.820 0.540 Download
MACCS fingerprints 0.730 0.730 0.730 0.730 0.820 0.470 Download
Daylight fingerprints 0.670 0.820 0.740 0.720 0.830 0.490 Download
ECFP2 fingerprints 0.680 0.740 0.710 0.700 0.850 0.420 Download
ECFP4 fingerprints 0.790 0.710 0.750 0.760 0.860 0.510 Download
ECFP6 fingerprints 0.860 0.720 0.790 0.800 0.870 0.590 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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