Target name

P48039: Melatonin receptor type 1A


  Protein function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

  Database links

Uniprot primary ID P48039
GRCP SARfari Variant Name hMTNR1A_197
PDB ID
DrugBank ID DB06594 DB00980 DB01065
BioGrid ID 110639
GuidetoPHARMACOLOGY ID 287
PharmGKB ID PA31267
KEGG ID hsa:4543
Entrez Gene (Gene ID) 4543
BindingDB P48039

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.93 0.73 0.83 0.84 0.88 0.67 Download
FP4 fingerprints 0.920 0.770 0.840 0.850 0.880 0.690 Download
MACCS fingerprints 0.890 0.760 0.830 0.840 0.880 0.660 Download
Daylight fingerprints 0.700 0.750 0.720 0.720 0.780 0.450 Download
ECFP2 fingerprints 0.970 0.780 0.880 0.890 0.900 0.770 Download
ECFP4 fingerprints 0.970 0.790 0.880 0.890 0.920 0.780 Download
ECFP6 fingerprints 0.960 0.800 0.880 0.890 0.920 0.770 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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