Target name

P49019: Hydroxycarboxylic acid receptor 3


  Protein function

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

  Database links

Uniprot primary ID P49019
GRCP SARfari Variant Name hHM74_200
PDB ID
DrugBank ID DB00627
BioGrid ID
GuidetoPHARMACOLOGY ID 313
PharmGKB ID PA165512827
KEGG ID hsa:8843
Entrez Gene (Gene ID) 8843
BindingDB P49019

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.95 0.87 0.91 0.91 0.96 0.82 Download
FP4 fingerprints 0.950 0.870 0.910 0.910 0.950 0.820 Download
MACCS fingerprints 0.980 0.870 0.920 0.930 0.950 0.850 Download
Daylight fingerprints 0.750 0.810 0.780 0.770 0.860 0.560 Download
ECFP2 fingerprints 0.960 0.860 0.910 0.910 0.930 0.820 Download
ECFP4 fingerprints 0.980 0.860 0.920 0.920 0.970 0.840 Download
ECFP6 fingerprints 0.980 0.860 0.920 0.920 0.960 0.840 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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