Target name

P49146: Neuropeptide Y receptor type 2


  Protein function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

  Database links

Uniprot primary ID P49146
GRCP SARfari Variant Name hNPY2R_201
PDB ID 2IK3
DrugBank ID DB00847
BioGrid ID
GuidetoPHARMACOLOGY ID 306
PharmGKB ID PA31741
KEGG ID hsa:4887
Entrez Gene (Gene ID) 4887
BindingDB P49146

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.66 0.88 0.77 0.74 0.79 0.55 Download
FP4 fingerprints 0.580 0.880 0.730 0.680 0.740 0.480 Download
MACCS fingerprints 0.570 0.870 0.720 0.670 0.740 0.460 Download
Daylight fingerprints 0.650 0.880 0.760 0.730 0.750 0.540 Download
ECFP2 fingerprints 0.490 0.960 0.720 0.640 0.750 0.500 Download
ECFP4 fingerprints 0.500 0.960 0.730 0.650 0.800 0.520 Download
ECFP6 fingerprints 0.490 0.990 0.740 0.650 0.820 0.550 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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