Target name

P49285: Melatonin receptor type 1A


  Protein function

High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).

  Database links

Uniprot primary ID P49285
GRCP SARfari Variant Name ggMTNR1A_1520
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID gga:396319
Entrez Gene (Gene ID) 396319
BindingDB P49285

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.99 0.9 0.95 0.95 0.97 0.9 Download
FP4 fingerprints 0.990 0.930 0.960 0.960 0.960 0.910 Download
MACCS fingerprints 0.990 0.920 0.960 0.960 0.970 0.910 Download
Daylight fingerprints 0.940 0.780 0.860 0.870 0.890 0.730 Download
ECFP2 fingerprints 0.990 0.920 0.960 0.960 0.970 0.910 Download
ECFP4 fingerprints 1.000 0.930 0.960 0.960 0.970 0.930 Download
ECFP6 fingerprints 0.990 0.930 0.960 0.960 0.970 0.920 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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