Target name

P49286: Melatonin receptor type 1B


  Protein function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

  Database links

Uniprot primary ID P49286
GRCP SARfari Variant Name hMTNR1B_203
PDB ID
DrugBank ID DB06594 DB00980 DB01065
BioGrid ID 110640
GuidetoPHARMACOLOGY ID 288
PharmGKB ID PA31268
KEGG ID hsa:4544
Entrez Gene (Gene ID) 4544
BindingDB P49286

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.93 0.76 0.84 0.85 0.9 0.69 Download
FP4 fingerprints 0.890 0.770 0.830 0.840 0.870 0.670 Download
MACCS fingerprints 0.910 0.770 0.840 0.850 0.870 0.680 Download
Daylight fingerprints 0.710 0.740 0.720 0.720 0.780 0.450 Download
ECFP2 fingerprints 0.970 0.770 0.870 0.880 0.890 0.760 Download
ECFP4 fingerprints 0.980 0.780 0.880 0.890 0.920 0.770 Download
ECFP6 fingerprints 0.970 0.790 0.880 0.890 0.920 0.770 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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