Target name

P50406: 5-hydroxytryptamine receptor 6


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:

  Database links

Uniprot primary ID P50406
GRCP SARfari Variant Name h5HT6_209
PDB ID
DrugBank ID DB00458 DB01142 DB00477 DB00334 DB06216 DB04946 DB01224 DB00321 DB01049 DB00408 DB00363 DB00246 DB06148 DB00543 DB00540 DB06144 DB01238
BioGrid ID 109594
GuidetoPHARMACOLOGY ID 11
PharmGKB ID PA29560
KEGG ID hsa:3362
Entrez Gene (Gene ID) 3362
BindingDB P50406

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.93 0.86 0.85 0.94 0.73 Download
FP4 fingerprints 0.860 0.830 0.850 0.850 0.930 0.700 Download
MACCS fingerprints 0.780 0.890 0.830 0.820 0.870 0.670 Download
Daylight fingerprints 0.770 0.870 0.820 0.810 0.860 0.650 Download
ECFP2 fingerprints 0.910 0.920 0.910 0.910 0.970 0.830 Download
ECFP4 fingerprints 0.900 0.950 0.930 0.920 0.970 0.850 Download
ECFP6 fingerprints 0.890 0.960 0.930 0.920 0.970 0.850 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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