Target name

P51050: Melatonin receptor type 1B


  Protein function

High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).

  Database links

Uniprot primary ID P51050
GRCP SARfari Variant Name ggMTNR1B_1530
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID gga:396338
Entrez Gene (Gene ID) 396338
BindingDB P51050

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.99 0.88 0.94 0.94 0.96 0.88 Download
FP4 fingerprints 0.980 0.910 0.950 0.950 0.960 0.900 Download
MACCS fingerprints 0.990 0.920 0.950 0.950 0.960 0.900 Download
Daylight fingerprints 0.930 0.820 0.870 0.880 0.900 0.750 Download
ECFP2 fingerprints 0.990 0.920 0.950 0.960 0.960 0.910 Download
ECFP4 fingerprints 1.000 0.930 0.960 0.960 0.970 0.930 Download
ECFP6 fingerprints 0.990 0.920 0.960 0.960 0.970 0.920 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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