Target name

P51677: C-C chemokine receptor type 3


  Protein function

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

  Database links

Uniprot primary ID P51677
GRCP SARfari Variant Name hCCR3_211
PDB ID
DrugBank ID
BioGrid ID 107637
GuidetoPHARMACOLOGY ID 60
PharmGKB ID PA26168
KEGG ID
Entrez Gene (Gene ID) 1232
BindingDB P51677

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.9 0.87 0.87 0.94 0.74 Download
FP4 fingerprints 0.770 0.870 0.820 0.810 0.900 0.640 Download
MACCS fingerprints 0.830 0.840 0.840 0.840 0.910 0.670 Download
Daylight fingerprints 0.830 0.780 0.810 0.810 0.860 0.610 Download
ECFP2 fingerprints 0.880 0.930 0.900 0.900 0.970 0.800 Download
ECFP4 fingerprints 0.870 0.960 0.910 0.910 0.980 0.830 Download
ECFP6 fingerprints 0.860 0.980 0.920 0.910 0.980 0.840 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn