Target name

P51679: C-C chemokine receptor type 4


  Protein function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

  Database links

Uniprot primary ID P51679
GRCP SARfari Variant Name hCCR4_212
PDB ID
DrugBank ID
BioGrid ID 107638
GuidetoPHARMACOLOGY ID 61
PharmGKB ID PA26169
KEGG ID hsa:1233
Entrez Gene (Gene ID) 1233
BindingDB P51679

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.74 0.74 0.74 0.82 0.48 Download
FP4 fingerprints 0.800 0.620 0.710 0.740 0.730 0.430 Download
MACCS fingerprints 0.750 0.640 0.690 0.710 0.740 0.390 Download
Daylight fingerprints 0.610 0.800 0.710 0.680 0.790 0.430 Download
ECFP2 fingerprints 0.870 0.620 0.750 0.770 0.750 0.510 Download
ECFP4 fingerprints 0.880 0.700 0.790 0.810 0.830 0.600 Download
ECFP6 fingerprints 0.870 0.750 0.810 0.820 0.850 0.620 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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