Target name

P51681: C-C chemokine receptor type 5


  Protein function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

  Database links

Uniprot primary ID P51681
GRCP SARfari Variant Name hCCR5_213
PDB ID 1NE0 4MBS 1ND8 1OPN 2RLL 2RRS 2L87 1OPT 2MZX 1OPW
DrugBank ID DB04835
BioGrid ID 107639
GuidetoPHARMACOLOGY ID 62
PharmGKB ID PA26170
KEGG ID hsa:1234
Entrez Gene (Gene ID) 1234
BindingDB P51681

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.88 0.85 0.87 0.87 0.93 0.73 Download
FP4 fingerprints 0.900 0.850 0.880 0.880 0.930 0.750 Download
MACCS fingerprints 0.900 0.770 0.830 0.840 0.910 0.670 Download
Daylight fingerprints 0.830 0.890 0.860 0.860 0.910 0.720 Download
ECFP2 fingerprints 0.910 0.930 0.920 0.920 0.970 0.840 Download
ECFP4 fingerprints 0.900 0.970 0.930 0.930 0.970 0.870 Download
ECFP6 fingerprints 0.900 0.970 0.940 0.930 0.970 0.870 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn