Target name

P54833: Beta-2 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

  Database links

Uniprot primary ID P54833
GRCP SARfari Variant Name cB2AR_1543
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID cfa:403910
Entrez Gene (Gene ID) 403910
BindingDB P54833

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.65 0.75 0.77 0.85 0.5 Download
FP4 fingerprints 0.870 0.650 0.760 0.780 0.800 0.530 Download
MACCS fingerprints 0.830 0.600 0.710 0.740 0.770 0.440 Download
Daylight fingerprints 0.780 0.630 0.700 0.720 0.750 0.410 Download
ECFP2 fingerprints 0.810 0.540 0.670 0.710 0.780 0.360 Download
ECFP4 fingerprints 0.900 0.640 0.770 0.800 0.860 0.570 Download
ECFP6 fingerprints 0.900 0.710 0.800 0.820 0.870 0.620 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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