Target name

P56450: Melanocortin receptor 4


  Protein function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

  Database links

Uniprot primary ID P56450
GRCP SARfari Variant Name mMC4R_1545
PDB ID
DrugBank ID
BioGrid ID 201341
GuidetoPHARMACOLOGY ID 285
PharmGKB ID
KEGG ID mmu:17202
Entrez Gene (Gene ID) 17202
BindingDB P56450

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.88 0.63 0.76 0.78 0.82 0.53 Download
FP4 fingerprints 0.850 0.690 0.770 0.790 0.810 0.560 Download
MACCS fingerprints 0.860 0.640 0.750 0.780 0.790 0.520 Download
Daylight fingerprints 0.860 0.630 0.750 0.770 0.780 0.510 Download
ECFP2 fingerprints 0.840 0.680 0.760 0.780 0.810 0.530 Download
ECFP4 fingerprints 0.840 0.750 0.800 0.810 0.830 0.600 Download
ECFP6 fingerprints 0.840 0.800 0.820 0.820 0.840 0.630 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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