Target name

P56481: Gastrin/cholecystokinin type B receptor


  Protein function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

  Database links

Uniprot primary ID P56481
GRCP SARfari Variant Name mCCKBR_1547
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 77
PharmGKB ID
KEGG ID mmu:12426
Entrez Gene (Gene ID) 12426
BindingDB P56481

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.92 0.88 0.9 0.9 0.94 0.8 Download
FP4 fingerprints 0.930 0.820 0.880 0.880 0.940 0.760 Download
MACCS fingerprints 0.880 0.840 0.860 0.860 0.910 0.720 Download
Daylight fingerprints 0.880 0.860 0.870 0.870 0.910 0.730 Download
ECFP2 fingerprints 0.960 0.900 0.930 0.930 0.970 0.870 Download
ECFP4 fingerprints 0.950 0.920 0.940 0.940 0.980 0.880 Download
ECFP6 fingerprints 0.950 0.930 0.940 0.940 0.980 0.880 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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