Target name

P61073: C-X-C chemokine receptor type 4

  Protein function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

  Database links

Uniprot primary ID P61073
GRCP SARfari Variant Name hCXCR4_144
PDB ID 4RWS 3OE0 2K03 3ODU 2K05 2K04 3OE6 3OE9 3OE8
DrugBank ID DB00452 DB06809
BioGrid ID 113607
PharmGKB ID PA27058
KEGG ID hsa:7852
Entrez Gene (Gene ID) 7852
BindingDB P61073

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.8 0.79 0.79 0.8 0.9 0.59 Download
FP4 fingerprints 0.760 0.780 0.770 0.770 0.860 0.540 Download
MACCS fingerprints 0.800 0.840 0.820 0.820 0.880 0.640 Download
Daylight fingerprints 0.710 0.790 0.750 0.740 0.840 0.490 Download
ECFP2 fingerprints 0.770 0.900 0.830 0.820 0.910 0.670 Download
ECFP4 fingerprints 0.770 0.910 0.840 0.830 0.930 0.690 Download
ECFP6 fingerprints 0.720 0.940 0.830 0.810 0.930 0.680 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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