Target name

P79400: 5-hydroxytryptamine receptor 1D


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity).

  Database links

Uniprot primary ID P79400
GRCP SARfari Variant Name sus5HT1D_1577
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID)
BindingDB P79400

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.8 0.92 0.86 0.85 0.87 0.72 Download
FP4 fingerprints 0.820 0.950 0.880 0.880 0.890 0.770 Download
MACCS fingerprints 0.770 0.930 0.850 0.830 0.880 0.700 Download
Daylight fingerprints 0.820 0.870 0.850 0.840 0.830 0.700 Download
ECFP2 fingerprints 0.790 0.920 0.850 0.840 0.830 0.710 Download
ECFP4 fingerprints 0.800 0.940 0.870 0.860 0.880 0.740 Download
ECFP6 fingerprints 0.790 0.950 0.870 0.860 0.890 0.750 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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