Target name

Q01726: Melanocyte-stimulating hormone receptor


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

  Database links

Uniprot primary ID Q01726
GRCP SARfari Variant Name hMC1R_219
PDB ID
DrugBank ID
BioGrid ID 110327
GuidetoPHARMACOLOGY ID 282
PharmGKB ID PA30673
KEGG ID hsa:4157
Entrez Gene (Gene ID) 4157
BindingDB Q01726

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.89 0.79 0.84 0.85 0.87 0.68 Download
FP4 fingerprints 0.890 0.750 0.820 0.830 0.870 0.640 Download
MACCS fingerprints 0.790 0.790 0.790 0.790 0.840 0.570 Download
Daylight fingerprints 0.810 0.800 0.800 0.800 0.840 0.600 Download
ECFP2 fingerprints 0.830 0.790 0.810 0.810 0.890 0.620 Download
ECFP4 fingerprints 0.820 0.800 0.810 0.810 0.890 0.620 Download
ECFP6 fingerprints 0.780 0.820 0.800 0.800 0.890 0.610 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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