Target name

Q01727: Melanocyte-stimulating hormone receptor


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

  Database links

Uniprot primary ID Q01727
GRCP SARfari Variant Name mMC1R_1596
PDB ID
DrugBank ID
BioGrid ID 201338
GuidetoPHARMACOLOGY ID 282
PharmGKB ID
KEGG ID mmu:17199
Entrez Gene (Gene ID) 17199
BindingDB Q01727

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.89 0.72 0.81 0.82 0.85 0.63 Download
FP4 fingerprints 0.910 0.710 0.810 0.830 0.840 0.640 Download
MACCS fingerprints 0.920 0.720 0.820 0.840 0.840 0.650 Download
Daylight fingerprints 0.850 0.750 0.800 0.810 0.840 0.610 Download
ECFP2 fingerprints 0.920 0.720 0.820 0.840 0.870 0.650 Download
ECFP4 fingerprints 0.910 0.740 0.820 0.840 0.890 0.660 Download
ECFP6 fingerprints 0.870 0.750 0.810 0.820 0.890 0.630 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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