Target name

Q02152: 5-hydroxytryptamine receptor 2B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca

  Database links

Uniprot primary ID Q02152
GRCP SARfari Variant Name m5HT2B_1598
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 7
PharmGKB ID
KEGG ID mmu:15559
Entrez Gene (Gene ID) 15559
BindingDB Q02152

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.96 0.8 0.88 0.89 0.93 0.77 Download
FP4 fingerprints 0.850 0.800 0.830 0.830 0.920 0.650 Download
MACCS fingerprints 0.840 0.860 0.850 0.850 0.930 0.700 Download
Daylight fingerprints 0.700 0.790 0.750 0.730 0.840 0.500 Download
ECFP2 fingerprints 0.960 0.830 0.890 0.900 0.950 0.800 Download
ECFP4 fingerprints 0.960 0.900 0.930 0.930 0.970 0.860 Download
ECFP6 fingerprints 0.960 0.910 0.940 0.940 0.970 0.870 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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