Target name

Q13258: Prostaglandin D2 receptor


  Protein function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

  Database links

Uniprot primary ID Q13258
GRCP SARfari Variant Name hPTGDR_220
PDB ID
DrugBank ID DB00716
BioGrid ID 111701
GuidetoPHARMACOLOGY ID 338
PharmGKB ID PA285
KEGG ID hsa:5729
Entrez Gene (Gene ID) 5729
BindingDB Q13258

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.81 0.9 0.85 0.85 0.93 0.71 Download
FP4 fingerprints 0.910 0.810 0.860 0.870 0.920 0.720 Download
MACCS fingerprints 0.700 0.830 0.770 0.750 0.860 0.540 Download
Daylight fingerprints 0.770 0.720 0.750 0.750 0.770 0.490 Download
ECFP2 fingerprints 0.920 0.870 0.900 0.900 0.950 0.790 Download
ECFP4 fingerprints 0.910 0.910 0.910 0.910 0.970 0.830 Download
ECFP6 fingerprints 0.890 0.930 0.910 0.910 0.970 0.820 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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