Target name

Q13639: 5-hydroxytryptamine receptor 4


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

  Database links

Uniprot primary ID Q13639
GRCP SARfari Variant Name h5HT4_223
PDB ID
DrugBank ID DB00904 DB08810 DB00604 DB01233 DB01049
BioGrid ID
GuidetoPHARMACOLOGY ID 9
PharmGKB ID PA29557
KEGG ID hsa:3360
Entrez Gene (Gene ID) 3360
BindingDB Q13639

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.77 0.82 0.8 0.79 0.88 0.59 Download
FP4 fingerprints 0.750 0.760 0.750 0.750 0.850 0.510 Download
MACCS fingerprints 0.810 0.720 0.770 0.780 0.850 0.530 Download
Daylight fingerprints 0.560 0.910 0.740 0.680 0.870 0.510 Download
ECFP2 fingerprints 0.830 0.780 0.800 0.810 0.880 0.610 Download
ECFP4 fingerprints 0.850 0.830 0.840 0.840 0.900 0.680 Download
ECFP6 fingerprints 0.800 0.830 0.820 0.820 0.910 0.640 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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