Target name

Q15722: Leukotriene B4 receptor 1


  Protein function

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

  Database links

Uniprot primary ID Q15722
GRCP SARfari Variant Name hLTB4R_248
PDB ID
DrugBank ID
BioGrid ID 107645
GuidetoPHARMACOLOGY ID 267
PharmGKB ID PA30476
KEGG ID hsa:1241
Entrez Gene (Gene ID) 1241
BindingDB Q15722

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.88 0.87 0.87 0.94 0.74 Download
FP4 fingerprints 0.940 0.860 0.900 0.900 0.930 0.790 Download
MACCS fingerprints 0.890 0.850 0.870 0.870 0.910 0.740 Download
Daylight fingerprints 0.910 0.750 0.830 0.840 0.860 0.670 Download
ECFP2 fingerprints 0.940 0.890 0.920 0.920 0.970 0.830 Download
ECFP4 fingerprints 0.950 0.910 0.930 0.930 0.980 0.850 Download
ECFP6 fingerprints 0.920 0.930 0.930 0.930 0.970 0.860 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn