Target name

Q28838: Alpha-2A adrenergic receptor


  Protein function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).

  Database links

Uniprot primary ID Q28838
GRCP SARfari Variant Name bA2AA_1607
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:282135
Entrez Gene (Gene ID) 282135
BindingDB Q28838

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.79 0.8 0.81 0.89 0.61 Download
FP4 fingerprints 0.820 0.720 0.770 0.780 0.860 0.550 Download
MACCS fingerprints 0.860 0.800 0.830 0.830 0.880 0.650 Download
Daylight fingerprints 0.720 0.710 0.710 0.720 0.760 0.430 Download
ECFP2 fingerprints 0.900 0.780 0.840 0.850 0.900 0.690 Download
ECFP4 fingerprints 0.970 0.800 0.880 0.890 0.930 0.770 Download
ECFP6 fingerprints 0.980 0.810 0.890 0.900 0.930 0.800 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn