Target name

Q62053: Prostaglandin E2 receptor EP2 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

  Database links

Uniprot primary ID Q62053
GRCP SARfari Variant Name mPTGER2_1027
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 341
PharmGKB ID
KEGG ID mmu:19217
Entrez Gene (Gene ID) 19217
BindingDB Q62053

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.79 0.81 0.81 0.88 0.61 Download
FP4 fingerprints 0.620 0.780 0.700 0.680 0.810 0.400 Download
MACCS fingerprints 0.690 0.820 0.760 0.740 0.870 0.520 Download
Daylight fingerprints 0.820 0.790 0.810 0.810 0.840 0.610 Download
ECFP2 fingerprints 0.790 0.760 0.780 0.780 0.820 0.550 Download
ECFP4 fingerprints 0.840 0.800 0.820 0.820 0.870 0.640 Download
ECFP6 fingerprints 0.820 0.800 0.810 0.810 0.880 0.620 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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