Target name

Q62758: 5-hydroxytryptamine receptor 4


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

  Database links

Uniprot primary ID Q62758
GRCP SARfari Variant Name r5HT4_1029
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 9
PharmGKB ID
KEGG ID rno:25324
Entrez Gene (Gene ID) 25324
BindingDB Q62758

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.85 0.84 0.84 0.9 0.68 Download
FP4 fingerprints 0.790 0.800 0.800 0.800 0.890 0.590 Download
MACCS fingerprints 0.730 0.830 0.780 0.770 0.860 0.570 Download
Daylight fingerprints 0.850 0.800 0.830 0.830 0.850 0.650 Download
ECFP2 fingerprints 0.830 0.790 0.810 0.810 0.880 0.620 Download
ECFP4 fingerprints 0.840 0.850 0.840 0.840 0.920 0.690 Download
ECFP6 fingerprints 0.840 0.860 0.850 0.850 0.930 0.700 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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