Target name

Q63931: Cholecystokinin receptor type A


  Protein function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

  Database links

Uniprot primary ID Q63931
GRCP SARfari Variant Name cavCCKAR_1038
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID) 100719593
BindingDB Q63931

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.9 0.95 0.92 0.92 0.97 0.85 Download
FP4 fingerprints 0.900 0.920 0.910 0.910 0.940 0.820 Download
MACCS fingerprints 0.900 0.900 0.900 0.900 0.940 0.800 Download
Daylight fingerprints 0.880 0.990 0.930 0.930 0.960 0.870 Download
ECFP2 fingerprints 0.890 0.910 0.900 0.900 0.960 0.810 Download
ECFP4 fingerprints 0.890 0.950 0.920 0.920 0.980 0.840 Download
ECFP6 fingerprints 0.890 0.990 0.940 0.940 0.980 0.880 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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