Target name

Q75Z89: 5-hydroxytryptamine receptor 2A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca

  Database links

Uniprot primary ID Q75Z89
GRCP SARfari Variant Name b5HT2A_1254
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:407230
Entrez Gene (Gene ID) 407230
BindingDB Q75Z89

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.62 0.72 0.75 0.75 0.46 Download
FP4 fingerprints 0.800 0.670 0.730 0.750 0.760 0.470 Download
MACCS fingerprints 0.760 0.700 0.730 0.740 0.710 0.460 Download
Daylight fingerprints 0.850 0.610 0.730 0.760 0.730 0.470 Download
ECFP2 fingerprints 0.780 0.620 0.700 0.720 0.680 0.410 Download
ECFP4 fingerprints 0.810 0.670 0.740 0.760 0.790 0.480 Download
ECFP6 fingerprints 0.820 0.700 0.760 0.770 0.810 0.520 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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