Target name

Q8TDS4: Hydroxycarboxylic acid receptor 2


  Protein function

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

  Database links

Uniprot primary ID Q8TDS4
GRCP SARfari Variant Name hHM74a_31
PDB ID
DrugBank ID DB00627
BioGrid ID
GuidetoPHARMACOLOGY ID 312
PharmGKB ID PA165961843
KEGG ID hsa:338442
Entrez Gene (Gene ID) 338442
BindingDB Q8TDS4

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.85 0.81 0.83 0.83 0.88 0.66 Download
FP4 fingerprints 0.940 0.740 0.840 0.860 0.890 0.700 Download
MACCS fingerprints 0.860 0.750 0.800 0.810 0.870 0.610 Download
Daylight fingerprints 0.840 0.700 0.770 0.780 0.820 0.540 Download
ECFP2 fingerprints 0.960 0.770 0.870 0.880 0.900 0.750 Download
ECFP4 fingerprints 0.980 0.800 0.890 0.900 0.930 0.790 Download
ECFP6 fingerprints 0.970 0.800 0.890 0.890 0.940 0.780 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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