Target name

Q8TDU6: G-protein coupled bile acid receptor 1


  Protein function

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

  Database links

Uniprot primary ID Q8TDU6
GRCP SARfari Variant Name hBG37_45
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 37
PharmGKB ID PA134903170
KEGG ID hsa:151306
Entrez Gene (Gene ID) 151306
BindingDB Q8TDU6

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.7 0.92 0.81 0.79 0.81 0.63 Download
FP4 fingerprints 0.700 0.860 0.780 0.760 0.780 0.570 Download
MACCS fingerprints 0.700 0.820 0.760 0.740 0.770 0.520 Download
Daylight fingerprints 0.700 0.830 0.760 0.750 0.740 0.530 Download
ECFP2 fingerprints 0.700 0.830 0.760 0.750 0.760 0.530 Download
ECFP4 fingerprints 0.700 0.830 0.760 0.750 0.800 0.530 Download
ECFP6 fingerprints 0.700 0.850 0.780 0.760 0.810 0.560 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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