Target name

Q91ZY1: Histamine H4 receptor


  Protein function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity).

  Database links

Uniprot primary ID Q91ZY1
GRCP SARfari Variant Name rHRH4_1289
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 265
PharmGKB ID
KEGG ID rno:170704
Entrez Gene (Gene ID) 170704
BindingDB Q91ZY1

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.7 0.56 0.63 0.65 0.62 0.27 Download
FP4 fingerprints 0.650 0.530 0.590 0.610 0.570 0.180 Download
MACCS fingerprints 0.690 0.510 0.600 0.630 0.660 0.200 Download
Daylight fingerprints 0.510 0.610 0.560 0.540 0.640 0.130 Download
ECFP2 fingerprints 0.450 0.370 0.410 0.430 0.370 -0.180 Download
ECFP4 fingerprints 0.720 0.440 0.580 0.630 0.550 0.170 Download
ECFP6 fingerprints 0.750 0.450 0.600 0.650 0.630 0.210 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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