Target name

Q923Y8: Trace amine-associated receptor 1

  Protein function

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

  Database links

Uniprot primary ID Q923Y8
GRCP SARfari Variant Name mTA1_1148
DrugBank ID
BioGrid ID
KEGG ID mmu:111174
Entrez Gene (Gene ID) 111174
BindingDB Q923Y8

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 1.0 0.91 0.95 0.96 0.98 0.91 Download
FP4 fingerprints 0.970 0.870 0.920 0.930 0.980 0.850 Download
MACCS fingerprints 0.850 0.940 0.890 0.890 0.930 0.790 Download
Daylight fingerprints 0.820 0.790 0.810 0.810 0.880 0.610 Download
ECFP2 fingerprints 0.980 0.900 0.940 0.940 0.990 0.890 Download
ECFP4 fingerprints 1.000 0.930 0.960 0.970 1.000 0.930 Download
ECFP6 fingerprints 1.000 0.960 0.980 0.980 1.000 0.960 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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