Target name

Q92633: Lysophosphatidic acid receptor 1


  Protein function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.

  Database links

Uniprot primary ID Q92633
GRCP SARfari Variant Name hEDG2_237
PDB ID 4Z36 4Z35 4Z34
DrugBank ID
BioGrid ID 108226
GuidetoPHARMACOLOGY ID 272
PharmGKB ID PA162394187
KEGG ID hsa:1902
Entrez Gene (Gene ID) 1902
BindingDB Q92633

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.67 0.75 0.77 0.89 0.51 Download
FP4 fingerprints 0.930 0.660 0.790 0.820 0.830 0.610 Download
MACCS fingerprints 0.800 0.680 0.740 0.760 0.790 0.490 Download
Daylight fingerprints 0.790 0.590 0.690 0.720 0.750 0.390 Download
ECFP2 fingerprints 0.950 0.660 0.800 0.830 0.770 0.640 Download
ECFP4 fingerprints 0.950 0.670 0.810 0.830 0.810 0.650 Download
ECFP6 fingerprints 0.950 0.680 0.820 0.840 0.830 0.660 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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