Target name

Q92847: Growth hormone secretagogue receptor type 1


  Protein function

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

  Database links

Uniprot primary ID Q92847
GRCP SARfari Variant Name hGHSR_238
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 246
PharmGKB ID PA28677
KEGG ID hsa:2693
Entrez Gene (Gene ID) 2693
BindingDB Q92847

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.88 0.81 0.79 0.9 0.62 Download
FP4 fingerprints 0.770 0.780 0.780 0.780 0.870 0.550 Download
MACCS fingerprints 0.740 0.720 0.730 0.730 0.830 0.460 Download
Daylight fingerprints 0.720 0.820 0.770 0.760 0.830 0.550 Download
ECFP2 fingerprints 0.810 0.880 0.850 0.840 0.930 0.700 Download
ECFP4 fingerprints 0.870 0.920 0.890 0.890 0.950 0.790 Download
ECFP6 fingerprints 0.830 0.930 0.880 0.870 0.950 0.760 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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