Target name

Q969F8: KiSS-1 receptor

  Protein function

Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

  Database links

Uniprot primary ID Q969F8
GRCP SARfari Variant Name hGPR54_40
DrugBank ID
BioGrid ID 124162
PharmGKB ID PA28899
KEGG ID hsa:84634
Entrez Gene (Gene ID) 84634
BindingDB Q969F8

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.86 0.82 0.82 0.91 0.65 Download
FP4 fingerprints 0.920 0.780 0.850 0.860 0.900 0.710 Download
MACCS fingerprints 0.970 0.740 0.860 0.870 0.890 0.740 Download
Daylight fingerprints 0.970 0.780 0.870 0.880 0.880 0.760 Download
ECFP2 fingerprints 0.970 0.750 0.860 0.880 0.860 0.740 Download
ECFP4 fingerprints 0.970 0.780 0.880 0.890 0.870 0.770 Download
ECFP6 fingerprints 0.970 0.780 0.880 0.890 0.880 0.770 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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