Target name

Q99500: Sphingosine 1-phosphate receptor 3


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

  Database links

Uniprot primary ID Q99500
GRCP SARfari Variant Name hEDG3_239
PDB ID
DrugBank ID
BioGrid ID 108227
GuidetoPHARMACOLOGY ID 277
PharmGKB ID PA162402362
KEGG ID hsa:1903
Entrez Gene (Gene ID) 1903
BindingDB Q99500

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.76 0.82 0.79 0.79 0.85 0.59 Download
FP4 fingerprints 0.700 0.830 0.770 0.750 0.820 0.540 Download
MACCS fingerprints 0.580 0.850 0.710 0.670 0.810 0.440 Download
Daylight fingerprints 0.700 0.740 0.720 0.710 0.760 0.440 Download
ECFP2 fingerprints 0.710 0.850 0.780 0.770 0.850 0.570 Download
ECFP4 fingerprints 0.760 0.820 0.790 0.780 0.880 0.580 Download
ECFP6 fingerprints 0.760 0.850 0.810 0.800 0.880 0.620 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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