Target name

Q9H228: Sphingosine 1-phosphate receptor 5


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

  Database links

Uniprot primary ID Q9H228
GRCP SARfari Variant Name hEDG8_262
PDB ID
DrugBank ID DB08868
BioGrid ID 119793
GuidetoPHARMACOLOGY ID 279
PharmGKB ID PA162402378
KEGG ID hsa:53637
Entrez Gene (Gene ID) 53637
BindingDB Q9H228

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.88 0.87 0.88 0.88 0.92 0.75 Download
FP4 fingerprints 0.910 0.880 0.890 0.890 0.900 0.780 Download
MACCS fingerprints 0.880 0.880 0.880 0.880 0.900 0.760 Download
Daylight fingerprints 0.880 0.780 0.830 0.840 0.830 0.660 Download
ECFP2 fingerprints 0.910 0.880 0.900 0.900 0.920 0.790 Download
ECFP4 fingerprints 0.940 0.890 0.910 0.920 0.930 0.830 Download
ECFP6 fingerprints 0.930 0.900 0.910 0.920 0.930 0.830 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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