Target name

Q9H244: P2Y purinoceptor 12


  Protein function

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.

  Database links

Uniprot primary ID Q9H244
GRCP SARfari Variant Name hP2RY12_263
PDB ID 4PY0 4NTJ 4PXZ 1Y9C 1T78 1VZ1
DrugBank ID DB06209 DB00208 DB00759 DB00758 DB08816 DB00374 DB01240
BioGrid ID 122309
GuidetoPHARMACOLOGY ID 328
PharmGKB ID PA134971947
KEGG ID hsa:64805
Entrez Gene (Gene ID) 64805
BindingDB Q9H244

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.7 0.87 0.78 0.77 0.86 0.58 Download
FP4 fingerprints 0.770 0.820 0.800 0.790 0.840 0.600 Download
MACCS fingerprints 0.760 0.850 0.800 0.790 0.850 0.600 Download
Daylight fingerprints 0.650 0.880 0.760 0.730 0.860 0.540 Download
ECFP2 fingerprints 0.830 0.860 0.850 0.840 0.880 0.690 Download
ECFP4 fingerprints 0.850 0.870 0.860 0.860 0.900 0.720 Download
ECFP6 fingerprints 0.800 0.870 0.830 0.830 0.900 0.670 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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