Target name

Q9H3N8: Histamine H4 receptor


  Protein function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

  Database links

Uniprot primary ID Q9H3N8
GRCP SARfari Variant Name hHRH4_264
PDB ID
DrugBank ID DB06148 DB01142 DB00667 DB00477 DB00334 DB00321 DB00408 DB00363 DB00543
BioGrid ID
GuidetoPHARMACOLOGY ID 265
PharmGKB ID PA134982275
KEGG ID hsa:59340
Entrez Gene (Gene ID) 59340
BindingDB Q9H3N8

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.81 0.84 0.84 0.9 0.68 Download
FP4 fingerprints 0.900 0.740 0.820 0.830 0.860 0.640 Download
MACCS fingerprints 0.850 0.730 0.790 0.800 0.860 0.580 Download
Daylight fingerprints 0.770 0.720 0.740 0.750 0.790 0.480 Download
ECFP2 fingerprints 0.960 0.770 0.870 0.880 0.900 0.750 Download
ECFP4 fingerprints 0.960 0.810 0.890 0.890 0.930 0.780 Download
ECFP6 fingerprints 0.950 0.820 0.880 0.890 0.930 0.780 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn