Target name

Q9HBW0: Lysophosphatidic acid receptor 2


  Protein function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

  Database links

Uniprot primary ID Q9HBW0
GRCP SARfari Variant Name hEDG4_53
PDB ID 4P0C
DrugBank ID
BioGrid ID 114611
GuidetoPHARMACOLOGY ID 273
PharmGKB ID PA162394202
KEGG ID hsa:9170
Entrez Gene (Gene ID) 9170
BindingDB Q9HBW0

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.85 0.89 0.87 0.87 0.91 0.74 Download
FP4 fingerprints 0.820 0.870 0.850 0.840 0.850 0.690 Download
MACCS fingerprints 0.790 0.880 0.830 0.820 0.840 0.670 Download
Daylight fingerprints 0.830 0.760 0.800 0.800 0.820 0.600 Download
ECFP2 fingerprints 0.800 0.870 0.830 0.830 0.870 0.670 Download
ECFP4 fingerprints 0.880 0.870 0.880 0.880 0.920 0.750 Download
ECFP6 fingerprints 0.880 0.890 0.890 0.890 0.930 0.770 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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